The National AIDS Commission (NAC) was re-established in October 2018 as an Independent State Institution by the HIV and AIDS (Prevention and Management) Act Number 9 of 2018. It replaced the NAC Public Trust, which the Government of Malawi established in July 2001 to provide overall leadership and coordination of a Multi-Sectoral National Response to the HIV and AIDS pandemic. Prior to this, the National AIDS Control Program, under the Ministry of Health and Population, was mandated to coordinate a largely biomedical response to HIV and AIDS from 1989 to 2001. The evolution in the status of the institution followed the Government’s realization that the response to the HIV and AIDS pandemic required a multi-sectoral approach and interface with broader issues of population, economic development and management; social service provision, culture, community development, human rights as well as gender, among others. The re-establishment of NAC as an Independent State Institution through an Act of Parliament has enhanced the Commission’s core mandate of providing leadership and coordination of the National Response to HIV and AIDS. Its activities are guided by an independently constituted and professional Board of Commissioners.